Future Biomanufacturing Research Hub

工业生物技术（IB）正在进入一个充满机遇的黄金时代。生物技术的技术和科学进步彻底改变了我们合成选择性分子的能力，使我们能够获得可调节选择性和使用良性反应条件的新化学物质。这些发展现在可以与生物工业化的进步相结合，以产生创新的制造路线，由高通量和实时分析，过程自动化，人工智能和数据驱动科学提供支持。目前制造业的过度能源需求及其对昂贵和资源密集型材料的使用是不能再容忍的。对气候变化（碳排放）、社会健康（有毒废物流、污染）和环境（宝贵资源枯竭、废物积累）的影响有据可查，且不可持续。显而易见的是，依赖石化产品的经济无法支撑我们的商品消费速度，也无法支撑我们对廉价、易得材料的需求。新兴的生物经济提高了资源效率，减少了对化石资源的依赖，有望使社会摆脱当前制造业实践的许多缺点。通过创新的IB利用生物学的力量，FBRH将支持更安全、更清洁和更绿色的制造业供应链的发展。这是英国清洁增长战略的核心。EPSRC未来生物制造研究中心（FBRH）将提供生物制造工艺，以支持生物经济的快速崛起，并将英国置于全球经济清洁增长的前沿，在关键制造业-制药；附加值的化学物质;工程材料。FBRH将成为生物制造加速器，协调英国学术、HVM和工业能力，使完整的生物制造创新管道能够提供经济、稳健和可扩展的生物工艺，以满足社会和商业需求。FBRH为实现这一愿景制定了明确的战略。该战略通过解决整个制造生命周期，考虑规模放大、工艺强化、连续制造、集成和全过程建模等方面，解决了改变生物制造经济现实的需要。FBRH将解决快速提供新的生物催化剂、强大的工业宿主和新的生产技术的迫切需求，这些技术将使从概念验证到大规模生产的快速过渡成为可能。重点是通过在所有生产规模上的集成技术开发，利用英国范围内世界领先的研究专长和前沿科学技术，包括数据驱动的人工智能方法、自动化和从“生物工程”中出现的新技术，可预测地部署可持续和创新的生物制造技术。FBRH将在曼彻斯特大学的曼彻斯特生物技术研究所设立其中心，在合成生物学创新和知识中心（伦敦帝国理工学院）、生物化学工程高级中心（伦敦大学学院）、生物过程、环境和化学技术集团（诺丁汉大学）、英国催化中心（哈维尔）、工业生物技术创新中心（格拉斯哥）和工艺创新中心（威尔顿）。这种将英国领先的IB中心与工业相结合的合作方式将为英国制造业建立国际独特的资产。

Industrial Biotechnology (IB) is entering a golden age of opportunity. Technological and scientific advances in biotechnology have revolutionised our ability to synthesise molecules of choice, giving access to novel chemistries that enable tuneable selectivity and the use of benign reaction conditions. These developments can now be coupled to advances in the industrialisation of biology to generate innovative manufacturing routes, supported by high throughput and real-time analytics, process automation, artificial intelligence and data-driven science. The current excess energy demands of manufacturing and its use of expensive and resource intensive materials can no longer be tolerated. Impacts on climate change (carbon emissions), societal health (toxic waste streams, pollution) and the environment (depletion of precious resources, waste accumulation) are well documented and unsustainable. What is clear is that a petrochemical-dependent economy cannot support the rate at which we consume goods and the demand we place on cheap and easily accessible materials. The emergent bioeconomy, which fosters resource efficiency and reduced reliance on fossil resources, promises to free society from many of the shortcomings of current manufacturing practices. By harnessing the power of biology through innovative IB, the FBRH will support the development of safer, cleaner and greener manufacturing supply chains. This is at the core of the UKs Clean Growth strategy.The EPSRC Future Biomanufacturing Research Hub (FBRH) will deliver biomanufacturing processes to support the rapid emergence of the bioeconomy and to place the UK at the forefront of global economic Clean Growth in key manufacturing sectors - pharmaceuticals; value-added chemicals; engineering materials. The FBRH will be a biomanufacturing accelerator, coordinating UK academic, HVM catapult, and industrial capabilities to enable the complete biomanufacturing innovation pipeline to deliver economic, robust and scalable bioprocesses to meet societal and commercial demand.The FBRH has developed a clear strategy to achieve this vision. This strategy addresses the need to change the economic reality of biomanufacturing by addressing the entire manufacturing lifecycle, by considering aspects such as scale-up, process intensification, continuous manufacturing, integrated and whole-process modelling. The FBRH will address the urgent need to quickly deliver new biocatalysts, robust industrial hosts and novel production technologies that will enable rapid transition from proof-of-concept to manufacturing at scale. The emphasis is on predictable deployment of sustainable and innovative biomanufacturing technologies through integrated technology development at all scales of production, harnessing UK-wide world-leading research expertise and frontier science and technology, including data-driven AI approaches, automation and new technologies emerging from the 'engineering of biology'.The FBRH will have its Hub at the Manchester Institute of Biotechnology at The University of Manchester, with Spokes at the Innovation and Knowledge Centre for Synthetic Biology (Imperial College London), Advanced Centre for Biochemical Engineering (University College London), the Bioprocess, Environmental and Chemical Technologies Group (Nottingham University), the UK Catalysis Hub (Harwell), the Industrial Biotechnology Innovation Centre (Glasgow) and the Centre for Process Innovation (Wilton). This collaborative approach of linking the UK's leading IB centres that hold complementary expertise together with industry will establish an internationally unique asset for UK manufacturing.