CSF NEUROPEPTIDES AND PROSTAGLANDINS IN ALCOHOL WITHDRAWAL AND BRAIN DISEASE

酒精戒断症状的严重程度在酗酒者中进行了量化 在华盛顿退伍军人医院的神经科病房 行政医院。 脑脊液（CSF）样本重复 在戒断早期和所有症状消退后获得。 单胺类神经递质去甲肾上腺素及其受体的浓度 主要代谢产物MHPG在NIH进行测量。 显著正 去甲肾上腺素升高的指标之间存在相关性， 营业额和几个戒酒的迹象 一份关于 去甲肾上腺素的发现发表在《普通精神病学档案》上。 我们 正在继续努力，试图找出去甲肾上腺素能 酒精戒断期间的失调 因此，我们测量的是 和已知参与调节 去甲肾上腺素能突触与去甲肾上腺素同时起作用。 我们正在继续这项工作，试图找出去甲肾上腺素能神经元 酒精戒断期间的失调 因此，我们测量的是 和已知参与调节 去甲肾上腺素能突触与去甲肾上腺素同时起作用。 我们将这些神经调质的浓度与 CSF中去甲肾上腺素和MHPG的浓度以及严重程度 戒断症状

Severity of withdrawal symptoms from alcohol was quantified in alcoholics admitted to the Neurology Ward of the Washington, DC Veterans' Administration Hospital. Cerebrospinal fluid (CSF) samples were repeatedly obtained early during withdrawal and after all symptoms had subsided. Concentrations of the monoamine neurotransmitter norepinephrine and its major metabolite MHPG were measured at NIH. Significant positive correlations were observed between indices of elevated norepinephrine turnover and several signs of alcohol withdrawl. A manuscript on the norepinephrine findings is in press in Archives of General Psychiatry. We are continuing to work to try to identify causes for the noradrenergic dysregulation during alcohol withdrawal. Thus, we are measuring peptides and prostaglandins, known to participate in the regulation of the functioning of noradrenergic synapses simultaneously with norepinephrine. We are continuing this work to try to identify causes for the noradrenergic dysregulation during alcohol withdrawal. Thus, we are measuring peptides and prostaglandins, known to participate in the regulation of the functioning of noradrenergic synapses simultaneously with norepinephrine. We are correlating the concentrations of these neuromodulators with concentrations of norepinephrine and MHPG in the CSF and with the severity of withdrawal symptoms in our patients.