STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目的重点是参与监管的机制， 氧与血红蛋白的结合以及氧向 组织中 重点放在这些职能的方式， 随着年龄的增长而变化。 这些研究集中在 血红蛋白氧化，产生无功能血红蛋白 同时释放氧自由基。 增强o？ 这些在低氧条件下的氧化过程 作为组织和器官损伤的可能来源， 会在衰老过程中加剧 还包括以下研究： 是针对整个红细胞的稳定性， 红细胞膜

This project focuses on the mechanisms involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces non-function hemoglobin and the simultaneous release of oxyradicals. The enhancement o? these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.