RELATIONSHIP OF PSYCHOBIOLOGY TO PSYCHOPATHOLOGY IN ALCOHOLICS

酗酒和情感障碍经常发生在同一个人身上 在同一个家庭的成员中。这种联系可以代表共同的-- 由于偶然或(A)原因而存在的两种常见疾病 由潜在情感的自我用药引起的酒精中毒 精神障碍，或(B)酒精滥用的毒性作用导致的抑郁症。 研究表明，酒精可以极大地提高情感感。 幸福，但随着持续的醉酒，这种改善可能是 颠倒了。此外，在慢性实验性中毒期间，酗酒者不会 只会变得越来越沮丧，也会变得更加焦虑。 在这项协议中，我们建议表征某些生物化学方面的 当酒精中毒患者出现抑郁和焦虑时。为了做到这一点，我们 将检查脑脊液和血浆中的去甲肾上腺素(谎言和 站立)，尿儿茶酚胺代谢物，并使用药理学 使用乳酸、异丙肾上腺素和氯丙咪嗪的挑战范例。

Alcoholism and affective disorders frequently occur in the same individuals and in members of the same family. This association may represent the co- existence of two common disease entities due to chance or due to (a) alcoholism resulting from self medication of an underlying affective disorder, or (b) depression resulting from toxic effects of alcohol abuse. Studies have shown that alcohol may acutely improve the sense of affective well-being, but with continued intoxication this improvement may be reversed. Also, during chronic experimental intoxication, alcoholics not only become increasingly depressed but also more anxious. In this protocol we propose to characterize certain biochemical aspects of depression and anxiety as they occur in alcoholic patients. To do this, we will examine cerebrospinal fluid and plasma for norepinephrine (lying and standing), urine for catecholamine metabolites and employ pharmacological challenge paradigms using lactate, isoproterenol and chlorimipramine.