INTRAVENOUS PROCAINE IN ALCOHOLICS AND ADULT CHILDREN OF ALCOHOLICS

先前的研究表明，普鲁卡因对躁郁症和 边缘患者会引起不同的行为反应 从兴高采烈到焦虑不安。因为普鲁卡因被认为 有选择地刺激大脑的边缘结构，这是合理的 这些行为差异可能是由于神经临床 大脑这些区域的差异。来检验这一假设 酒精可能会改变我们给普鲁卡因注射的边缘功能 酗酒者，恐慌症患者，酗酒恐慌症患者 和控制。我们的结果显示，惊恐障碍患者 在普鲁卡因后更有可能经历恐慌性发作 控制。对我们结果的初步分析表明， 迷走神经张力不能完全解释脉搏频率的升高 在一次恐慌症发作期间。

Previous studies show that the administration of procaine to bipolar and borderline patients gives rise to a diversity of behavioral responses ranging from euphoria to dysphoria. Since procaine is believed to selectively stimulate the limbic structures of the brain, it is reasoned that these behavioral differences might result from neuroclinical differences in these regions of the brain. To test the hypothesis that alcohol might alter limbic function we administered procaine to alcoholics, patients with panic disorder, panic patients with alcoholism and controls. Our results show that patients with panic disorder were more likely to experience a panic attack following procaine than were controls. Preliminary analysis of our results suggest that changes in vagal tone do not completely explain the rise in pulse frequency seen during a panic attack.