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Control of gastrointestinal tumour progression by therapeutic interference with myeloid derived cells

Control of gastrointestinal tumour progression by therapeutic interference with myeloid derived cells
通过治疗干扰骨髓来源细胞来控制胃肠道肿瘤进展
批准号:
nhmrc : 1067244
负责人:
A/Pr Martin Lackmann
金额:
$50.59万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

项目摘要

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中文摘要
翻译
胃癌和结肠癌是主要的健康负担。尽管我们对导致这些癌症的突变的分子理解有所增加,但我们的治疗选择非常有限。在这里,我们将使用这些癌症的复杂和验证的小鼠模型来确定血液传播细胞如何促进这些癌症的生长和扩散。我们将使用这些模型来建立已经进行临床前测试的治疗药物的高效治疗组合。
英文摘要
Cancers of the stomach and the colon are a major health burden. Despite our increased molecular understanding of the mutation that cause these cancers our treatment options are very limited. Here we will use sophisticated and validated mouse models for these cancers to establish how blood-borne cells contribute to the growth and spreading of these cancer. We will use these models to establish highly effective treatment combinations of therapeutic agents that are already undergoing preclinical testing.
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Antibody-based inhibition of ADAM10 as cancer immunotherapy
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  • 项目类别:
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  • 资助金额:
    $43.53万
  • 财政年份:
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Can inhibition of myeloid cell function suppress gastro-intestinal cancer?
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  • 项目类别:
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Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment
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  • 项目类别:
    Project Grants
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  • 财政年份:
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    nhmrc : 1003908
  • 项目类别:
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  • 资助金额:
    $27.72万
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  • 负责人:
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海外基金