EFFECT ON AMPHETAMINE ON CEREBRAL BLOOD FLOW IN SCHIZOPHRENIA

在过去的一年里，我们试图描述认知的各个方面 精神分裂症的失败。特别是，我们有： 1.使用所谓的各种测试来检查工作记忆功能 通过延迟的中央执行、视觉、语言和从属系统 回应范式。 2.检查语义记忆，以确定是否存在组织混乱 可能会影响精神分裂症患者的能力 交流。我们正试图描述语义上的差异 口语流利度和语音口语流畅度我们使用不同的 确定是否存在过度激活语义的启动技术 精神分裂症患者与“思维障碍”相关的联想网络。 3.尝试检验妄想理论对幻觉行为的影响 精神分裂症的前提是与 启动动作和第二个监控动作的“中心”。我们已经使用了 延迟听觉反馈来评估这一理论。 4.研究抗精神病药对认知精神分裂症的影响。 评估患者在神经心理测试中的表现 接受氯氮平、氟哌啶醇或安慰剂治疗。 5.通过评估认知能力来投资神经心理学、专一性 患有躁郁症的双胞胎，额叶癫痫患者， 以及创伤性脑损伤的患者。 6.用自传测验评定精神分裂症患者的远距离记忆 知识、名人信息和语义信息。 7.测量苯丙胺对正常受试者认知的影响 不同认知任务交互作用对大脑的影响 血流通过PET 015测量。

For the past year we attempted to characterize various facets of cognitive failure in schizophrenia. In particular we have: 1. Examined working memory function using a variety of tests of so called central executive and visual and verbal and slave systems through delayed response paradigms. 2. Examining semantic memory in order to ascertain if disorganization might have effects on the ability of schizophrenic patients to communicate. We are trying to characterize differences between semantic verbal and fluency and phonological verbal fluency we are using various priming techniques to determine if there is overactivation semantic associative networks in schizophrenia that covary with "thought disorder." 3. Attempted to test the theory of delusion on hallucinatory behavior in schizophrenia that premises disconnection between a "center" that initiates action and a second "center" that monitors action. We have used delayed auditory feedback to assess this theory. 4. Examined the effects of neuroleptics on cognition schizophrenia by assessing patients' performance on neuropsychological test while they received clozapine, haloperidol or placebo. 5. Invested neuropsychological, specificity by assessing cognitive in twins discordant for bipolar illness, patients with frontal lobe epilepsy, and in patients with traumatic brain injury. 6. Assessed remote memory in schizophrenia in by testing auto biographical knowledge, information about famous people and semantic information. 7. Measured the effects of amphetamine on cognition in normal subjects and its effects while interacting with different cognitive tasks on cerebral blood flow by means of PET 015.