STATISTICAL COLLABORATION AND CONSULTATION

该项目包括广泛的统计合作， 与实验室和分支机构协商， 校内研究（Intramural Research），并与其他神经科学单位外 国家卫生研究院特别考虑到统计规划和设计 实验，数据统计分析和统计推断。 目前的研究实例包括： 来自天然和重组的α-甘露糖终止的葡糖脑苷脂酶 治疗患者的来源、临床病程和长期结局 Ceredase/TM治疗戈谢病的骨骼反应评价 接受Ceredase/TM治疗的戈谢病患者，纵向 法布里病临床病程的研究;临床试验 非氨酯用于治疗顽固性复杂部分性癫痫发作， 测量距最后一次癫痫发作的时间和癫痫发作类型对 通过PET测量的代谢变化，研究癫痫进展至 全身强直-阵挛性癫痫发作（ERB）; 环孢素对复发缓解型MS病变发展的影响，建模 DSG治疗复发-缓解型多发性硬化症的临床研究 复发缓解型MS的病变发展，监测MRI T2加权 复发-缓解型MS的影像学; B7：CD作用的测定 慢性复发性EAE中的28-CTLA-4相互作用;检查 复发缓解型患者的疾病白色物质蓄积 纳瓦霍部落神经系统疾病患病率研究 (ERB)经颅磁刺激异常易化反应的研究 PD患者中的刺激，识别与 钢琴家的“过度使用”综合征，三项IV-IG的临床试验， 神经肌肉疾病，双胞胎不一致的随访研究 麻痹性脊髓灰质炎和随后的脊髓灰质炎后综合征; 金刚烷胺治疗脊髓灰质炎后疲劳（MNB）的评价 偏侧帕金森病大鼠神经元发芽和行为恢复 羊膜细胞移植（SNB）;会诊的验证研究 由美国药物信息中心提供;神经性疾病的发生率研究 以色列全身肿瘤;关岛运动神经元疾病发病率研究 (NEB)快速循环双相情感障碍的马尔可夫模型的发展， 强光照射与热暴露之间关系的研究 绝经期妇女的闪光（NIMH）;无症状性卒中危险因素的研究 及其对后续中风生存率的影响，以及 中风后癫痫发作

This project encompasses a wide scope of statistical collaboration and consultation with laboratories and branches within the Division of Intramural Research (DIR), and with other neuroscience units outside NIH. Particular consideration is given to statistical planning and design of experiments, statistical analysis of data, and statistical inference. Examples of current studies include: clinical trial of bioequivalence of alpha- mannose-terminated glucocerebrosidase from natural and recombinant source, clinical course and long-term outcome of patients treated with Ceredase/TM in Gaucher's disease, evaluation of skeletal responses of patients with Gaucher's disease treated with Ceredase/TM ,longitudinal study of the clinical course of Fabry's disease (DMNB); clinical trials of felbamate for the treatment of intractable complex partial seizures, measurement of the effect of time from last seizure and seizure type on metabolic change as measured by PET, study of epilepsy progression to general tonic-clonic seizures (ERB); clinical trial of the effect of cyclosporine on lesion development in relapsing-remitting MS, modeling lesion recurrence in relapsing-remitting MS, clinical trial of DSG on lesion development in relapsing-remitting MS, monitoring MRI T2 weighted imaging in relapsing-remitting MS; determination of the role of B7:CD 28-CTLA-4 interaction in chronic relapsing EAE; examining the effect of accumulation of disease white matter in patients with relapsing-remitting MS (NIB); prevalence study of neurologic diseases in the Navajo tribe (ERB); study of abnormal facilitation response to transcranial magnetic stimulation in PD patients, identification of deficits associated with "over use" syndrome in pianists, three clinical trials of IV-IG in neuromuscular disorders, follow-up study of twins discordant for paralytic polio and subsequent post-polio syndrome; clinical trial of amantadine for the treatment of post-polio fatigue (MNB); evaluation of neuronal sprouting and behavioral recovery in hemiparkinsonian rats after amnion cell transplantation (SNB); validation study of consultations provided by U.S. drug information centers; incidence study of nervous system tumors in Israel; incidence study of motor neuron disease on Guam (NEB); development of Markov models for rapidly cycling bipolar disorder, examination of the relationship between bright light exposure and hot flashes in menopausal women (NIMH); studies of silent stroke risk factors and their implication for survival of a subsequent stroke, and risk of seizures following stroke.