CHARACTERIZATION OF THE WHHL RABBIT LIPOPROTEIN PHENOTYPES

兽医资源计划，国家研究资源中心， 建立了一个渡边高脂血症（WHHL）兔繁殖群， 作为调查人员的资源。 Watanabe等人报告说， 两种类型的WHHL兔-那些具有早期发育和高 冠状动脉粥样硬化（1型）和晚期 冠状动脉粥样硬化（2型）的发展和低发病率。 它 研究还表明，任何一种兔子都可以有选择地繁殖， 以产生表现出感兴趣的表型的后代。 近日 据报道，这两种类型的WHHL兔可以区分， 通过他们的脂蛋白表型。 将兔禁食过夜，并将血液收集在EDTA真空采血管中 第二天早上 琼脂糖凝胶电泳鉴定 脂蛋白表型 14只家兔的电泳分析 NCRR WHHL家兔菌落显示有两种脂蛋白表型： 一种是β-脂蛋白密度增加，另一种是 β-双峰。 这些表型与两种报告的表型相似 WHHL兔子的种类 NCRR WHHL家兔的表征， 表型将是有价值的研究人员谁想要使用它们， 他们的研究

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators. Watanabe et al reported that there are two types of WHHL rabbits--those with early development and high incidence of coronary atherosclerosis (type 1) and those with late development and low incidence of coronary atherosclerosis (type 2). It has also been shown that either type of rabbit can be selectively bred to produce progeny exhibiting the phenotype of interest. Recently, it was reported that these two types of WHHL rabbits can be differentiated by their lipoprotein phenotypes. Rabbits were fasted overnight and blood was collected in EDTA vacutainers the next morning. Agarose gel electrophoresis was used to identify the lipoprotein phenotypes. Electrophoretic analysis of 14 rabbits from the NCRR WHHL rabbit colony showed that there are two lipoprotein phenotypes: one with an increased density of beta-lipoprotein and another with a beta-doublet. These phenotypes are similar to those reported for the two types of WHHL rabbits. Characterization of the NCRR WHHL rabbits as to phenotype will be of value to investigators who want to use them for their studies.