BRAIN STRUCTURE AND FUNCTION IN DEVELOPMENTAL NEUROPSYCHOLOGICAL DISORDERS

磁共振成像和正电子发射断层扫描正在进行 用于评估正常对照组和对照组的神经解剖学和脑功能 发育障碍的受试者。参与的诊断小组 研究包括注意力缺陷多动障碍、自闭症、 儿童期起病的精神分裂症、阅读障碍、多维障碍 综合症，强迫症，口吃，西德纳姆舞蹈症， 和多发性抽动症。正常对照组作为对照组 对于发育障碍，并检查正常发育和 儿童和青少年的性别差异。 到目前为止，mri显示的是较小面积的拱顶。 和嘴小体在ADHD患者中的增加和增加 儿童发病时脑室大小和颞叶体积减少 精神分裂症患者。 磁共振成像对性别的区域脑体积和穹窿体部的研究 正常发展的差异揭示了令人惊讶的趋同 青春期的结构大小，而不是预期的分歧。 Sydenham舞蹈症患者尾状核有可量化的变化 细胞核形态似乎随着症状的严重程度而波动。 治疗后阅读障碍的O-15PET和功能磁共振研究目前正在进行 正在测试阅读的双路理论。

Magnetic resonance imaging and positron emission tomography are being used to assess neuroanatomy and brain function in normal controls and subjects with developmental disorders. Diagnostic groups involved in the studies include attention deficit hyperactivity disorder, autism, childhood onset schizophrenia, dyslexia, multi-dimensional impairment syndrome, obsessive compulsive disorder, stuttering, Sydenham's chorea, and Tourette's syndrome. The normal controls serve as a comparison group for the developmental disorders and to examine normal development and gender differences in children and adolescents. To date, MRI findings suggests smaller area measurements of the rostrum and rostral body of the corpus callosum in ADHD patients and increased ventricular size and decreased temporal lobe volume in childhood onset schizophrenics. MRI regional brain volume and corpus callosum studies of gender differences in normal development reveal a surprising convergence of structure size at puberty, instead of the anticipated divergence. Sydenham's chorea patients demonstrate quantifiable changes in caudate nucleus morphology which seem to fluctuate with the severity of symptoms. O-15 PET and functional MRI studies of remediated dyslexia are currently underway to test the dual-route theory of reading.