Cytokine responses within the GI tract dictate T cell fate and transplant outcome

澳大利亚每年有超过10，000人被诊断患有血癌，占癌症死亡人数的10%。干细胞移植仍然是这些疾病的治愈性疗法，但受到称为移植物抗宿主病（GVHD）的过程的限制，该过程导致高达50%的患者死亡。该项目将重点关注结肠内的免疫反应，作为引发致命GVHD的关键事件，定义将被转化为改善移植结果的新治疗方法。

Over 10,000 persons per year in Australia are diagnosed with a blood cancer, accounting for 10% of cancer deaths. Stem cell transplantation remains curative therapy for these diseases but is limited by a process known as graft-versus-host disease (GVHD), responsible for mortality in up to 50% of patients. This project will focus on immune responses within the colon as the critical event initiating lethal GVHD, defining new treatments that will be translated to improve transplant outcomes.