STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS

解释门静脉周围纤维化的新的动脉化 曼氏血吸虫卵周围的组织 对受感染的人、寄生虫产品进行内皮评估 细胞生长因子活性。非常强大的内皮细胞 可溶性抗原诱导活化和增殖 卵(海)，但不是成体血吸虫，在没有任何 免疫细胞或因子。来自日本血吸虫的SEA也刺激了 内皮细胞增殖，但程度要小得多 曼氏沙门氏菌、美空沙门氏菌和血瘤海沙门氏菌均不起作用。 刺激这些细胞增殖。所有的血管新生 到目前为止，已阐明的因子来自哺乳动物 消息来源。寄生的无脊椎动物能够 产生一种独特的血管生成物质或能够模拟一种 通常由寄主产生，具有重要的生物学意义 这意味着什么。

To account for the neo-arteriolization of the peri-portal fibrotic tissue around the eggs of Schistosoma mansoni in the livers of infected humans, parasite products were evaluated for endothelial cell growth factor activity. Very potent endothelial cell activation and proliferation were induced by soluble antigens from eggs (SEA) but not adult schistosomes, all in the absence of any immune cells or factors. SEA from S. japonicum also stimulated endothelial proliferation but to a much lesser degree than did that of S. mansoni; S. mekongi and S. hematobium SEA were ineffective in stimulating these cells to proliferate. All the angiogenic factors thus far elucidated have been derived from mammalian sources. That a parasitic invertebrate could be capable of producing a unique angiogenic substance or be able to mimic one normally produced by its host has important biological implications.