NEURON-SPECIFIC ENOLASE IN CHILDHOOD TUMORS

儿童实体瘤的诊断和治疗是 由于缺乏可辨别的特征，常常很困难。这 尤因肉瘤，神经母细胞瘤，原始的 软组织肉瘤，(偶尔)淋巴瘤。我们有 评估了一种特定的神经酶，神经元的存在- 石蜡切片中的特异烯醇化酶(NSE) 不同的儿童实体肿瘤组，包括以前 未被识别的神经肿瘤变种，采用 用NSE抗血清进行免疫细胞化学。我们找到了制服 所有神经肿瘤对这种抗体的反应性。没有交叉- 与非神经肿瘤的反应性，除了一例罕见的 分化型横纹肌肉瘤。我们的结论是 NSE是一种可靠的、易于检测的甚至原始的标记 儿童神经源性肿瘤。此外，我们还定义了 一种新描述的“圆形细胞”肿瘤的神经组织发生 胸壁类似于尤因肉瘤，即所谓的Askin 肿瘤，实际上是外周神经上皮瘤的一种形式。 最后，我们最近确认了SO的独特性质- 被称为周围神经上皮瘤，NSE阳性，但 它显示了混合神经和Schwannian形态 特点。

The diagnosis, and thus therapy, of solid tumors of childhood is often difficult due to lack of distinguishing characteristics. This is especially true of Ewing's sarcoma, neuroblastoma, primitive soft tissue sarcomas, and (occasionally) lymphoma. We have evaluated the presence of a specific neuronal enzyme, neurone- specific enolase (NSE), in paraffin-embedded sections of a diverse group of solid childhood tumors, including previously unrecognized variants of neural tumors, employing immunocytochemistry with antisera to NSE. We find uniform reactivity of all neural tumors with this antibody. No cross- reactivity with non-neural tumors, save a rare example of differentiated rhabdomyosarcoma, was found. We conclude that NSE is a reliable, readily detected marker in even primitive childhood tumors of neural origin. Also, we have defined the neural histogenesis of a newly described, "round cell" tumor of chest wall resembling Ewing's sarcoma, the so-called Askin tumor, which in reality is a form of peripheral neuroepithelioma. Finally, we have recently confirmed the unique character of so- called peripheral neuroepithelioma, which is NSE-positive but which displays hybrid neural and Schwannian morphologic characteristics.