THERAPEUTIC STUDIES IN MURINE LUPUS

富含多不饱和脂肪酸二十碳五烯酸的饮食 酸性，显著延缓(NZB)自身免疫的发展 X NZW)F1女性。即使在疾病发作之后，这也是有效的。 人体试验正在进行中。 环磷酰胺是治疗多种癌症的有效药物 与疾病的细胞基础无关的自身免疫菌株或 增殖细胞的性质(B细胞或T细胞)。这种疗法 对MRL-LPR/LPR淋巴结病有效 C3H/HeJ-GLD/GLD小鼠与BXSB冠脉病变 和(NZW×BXSB)F1小鼠以及大多数肾脏疾病 小鼠狼疮的例子。环磷酰胺显著降低 MRL-LPR/LPR小鼠淋巴组织中MYB RNA的升高 增加极低的胸腺MYB表达。 环孢素A是一种干扰T细胞功能的药物， 有效治疗关节炎、肾炎和 MRL-lpr/lpr小鼠的淋巴细胞增殖。 肿瘤坏死因子对(NZB×NZW)F1和MRL-LPR/LPR小鼠的治疗作用 在生命早期或在发病后开始有效 疾病。

A diet enriched in a polyunsaturated fatty acid, eicosapentaenoic acid, markedly retards the development of autoimmunity in (NZB x NZW)F1 females. This works even after the onset of disease. Human trials are being carried out. Cyclophosphamide is effective treatment in a variety of autoimmune strains unrelated to the cellular basis of illness or the nature (B or T cell) of the proliferating cells. This therapy is effective against the lymphadenopathy of MRL-lpr/lpr and C3H/HeJ-gld/gld mice and the coronary artery disease of BXSB and (NZW x BXSB)F1 mice as well as the renal disease of most examples of murine lupus. Cyclophosphamide markedly reduces the elevated myb RNA in MRL-lpr/lpr mice lymph nodes and increases the very low thymic myb expression. Cyclosporin A, a drug which interferes with T cell function, is effective treatment for the arthritis, nephritis, and lymphoproliferation of MRL-lpr/lpr mice. Treatment of (NZB x NZW)F1 and MRL-lpr/lpr mice with TNF is effective when started either early in life or after the onset of disease.