HORMONES, HORMONE RECEPTORS, & AGING - III. AGING & HUMAN ENDOCRINE REGULATION

在过去的一年里，我们的临床研究方向是(1) 区分初级衰老和年龄的影响-- 与男性垂体性腺功能相关的疾病和(2) 研究循环性类固醇之间的相互关系 激素水平与冠状动脉病变的各种危险因素 疾病(CAD)。我们测量了睾酮(T)、T结合和 促性腺激素在一大群健康男性和患有 良性或恶性肺部疾病。我们发现：(A)存在一个 垂体促性腺激素和睾丸的患病率增加 男性肺癌患者的功能障碍，程度较轻的良性患者 肺部疾病和(B)疾病的影响独立于和 数量上大于老化的。我们还测量了 53例男性健康体检前血浆睾酮和雌二醇水平 冠心病的发展与136例无病对照 CAD。我们发现T水平之间没有显著的关联， E_2，或T与E_2的比率以及随后的CAD的发展。我们 计划启动或继续对(A)影响的调查 肠外雌激素替代治疗对不同激素参数的影响 健康绝经后妇女骨代谢相关因素的研究 不同年龄，(B)性激素之间的相互关系 以及健康骑自行车和某些CAD危险因素 绝经后妇女，以及(C)老龄化对妇女的影响 男性和女性的脑下垂体肾上腺激素动态。

In the past year, our clinical studies have been oriented to (1) discriminating between the effects of primary aging vs. age- associated illness on pituitary gonadal function in men and (2) examining the interrelationships between circulating sex steroid hormone levels and various risk factors for coronary artery disease (CAD). We have measured testosterone (T), T binding, and gonadotropins in a large group of healthy men and men with benign or malignant lung disease. We found that: (a) there is an increased prevalence of both pituitary gonadotropic and testicular dysfunction in men with lung cancer and, to a lesser extent benign lung disease and (b) the effects of illness are independent of and quantitatively greater than those of aging. We also measured plasma levels of T and estradiol (E2) in 53 men prior to their development of CAD and in 136 controls who remained without CAD. We found no significant association between levels of T, E2, or the ratio T to E2 and subsequent development of CAD. We plan to initiate or continue investigations of (a) the effects of parenteral estrogen replacement on various hormonal parameters related to bone metabolism in healthy postmenopausal women of different ages, (b) the interrelationships between sex hormones and certain CAD risk factors in healthy cycling and postmenopausal women, and (c) the effects of aging on the pituitary adrenal hormone dynamics in men and women.