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MECHANISMS OF HISTAMINE RELEASE

MECHANISMS OF HISTAMINE RELEASE
组胺释放机制
批准号：
3839075
负责人：
R SIRAGANIAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3839075
关键词：
antibody receptor basophils biological models calcium channel histamine release immunoglobulin E immunoregulation inflammation ionophores lymphocyte proliferation mast cell mutant neoplastic cell culture for noncancer research secretion tissue /cell culture

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中文摘要
翻译
肥大细胞和血液嗜碱性粒细胞释放组胺的研究正在进行中
英文摘要
Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, other secretagogues, LHRH peptides, and the calcium ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
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