EFFECT OF CHRONIC SUBCUTANEOUS OR INTRAMURAL ADMINISTRATION OF HEPARIN

众所周知，肝素具有抗血栓、抗凝血剂和 抗增殖作用。我们假设慢性皮下注射 和/或直接壁内注射肝素可减少再狭窄 并抑制球囊血管成形术后的斑块生长。焦点 59例双侧股动脉致动脉粥样硬化 兔通过空气干燥、内膜损伤和2%的胆固醇饮食。 血管成形术后，兔子被分配到四种治疗中的一种 组。对照动脉(n=21)不接受额外的肝素。一秒钟 组20条动脉用多孔球囊治疗，球囊扩张 肝素(1500U)直接进入动脉壁。第三组(n=29) 皮下注射肝素(350U/kg/天)，共28天，第四次 肝素组(n=23)，皮下和壁内注射肝素。 球囊血管成形术后慢性皮下肝素治疗效果不佳 然而，在这个模型中，血管造影再狭窄的减少，绝对 与血管成形术前和斑块相比，管腔直径没有改善 斑块引起的面积和管腔狭窄百分比在 四个治疗组。肝素可以被输送到动脉粥样硬化症 使用多孔气囊治疗斑块，但这种治疗不会减少 在这个模型中，血管成形术后再狭窄。

Heparin is known to have antithrombotic, anticoagulant, and antiproliferative effects. We hypothesized that chronic subcutaneous and/or direct intramural administration of heparin would reduce restenosis and inhibit plaque growth following balloon angioplasty. Focal atherosclerosis was induced bilaterally in the femoral arteries of 59 rabbits by air desiccation intimal injury and a 2% cholesterol diet. After angioplasty, the rabbits were assigned to one of four treatment groups. Control arteries (n=21) received no additional heparin. A second group of 20 arteries was treated with a porous balloon which delivered heparin (1500 U) directly into the arterial wall. A third group (n=29) received subcutaneous heparin (350 U/kg/day) for 28 days, and a fourth group (n=23) was treated with subcutaneous and intramural heparin. Chronic subcutaneous heparin after balloon angioplasty results in a modest reduction in angiographic restenosis in this model, however, the absolute luminal diameter is not improved compared with pre-angioplasty and plaque area and percent luminal narrowing by plaque were not different among the four treatment groups. Heparin can be delivered into an atherosclerotic plaque using a porous balloon, but this treatment does not reduce restenosis after angioplasty in this model.