ASSESSMENT OF OPIOID AGONISTS AND ANTAGONISTS

对有阿片类药物滥用史的受试者进行了研究， 研究单位调查纳美芬的影响，一个新的 具有相对较少激动剂作用的研究性阿片类拮抗剂。 这项研究应该有助于确定 这种长效（数天）阿片类拮抗剂用于治疗 阿片类药物依赖者。 这项研究正在进行， 与化学和药物代谢实验室和 研究支援分支。 计划进行两项研究，第一项将评估 纳美芬的滥用责任，第二个将决定 纳美芬阻断主观和生理效应的功效 吗啡。 第一项研究已经完成。 结果表明 纳美芬没有产生典型的阿片类药物滥用倾向，但 副作用，如激动和易怒的感觉，肌肉 紧张、头痛和失眠可能会限制其作为可能的治疗方法的使用 阿片类药物依赖 第二项研究最近完成， 目前正在分析数据。 初步报告将在 1991年药物管制问题委员会会议上提出的报告 依赖。

Subjects with histories of opioid abuse were studied on the Residential Research Unit to investigate the effects of nalmefene, a new investigational opioid antagonist with relatively few agonist effects. This research should be useful in determining the possible utility of this long-acting (several days) opioid antagonist for the treatment of opioid dependent persons. This research is being conducted in collaboration with the Chemistry and Drug Metabolism Laboratory and the Research Support Branch. Two studies were planned, the first will assess the abuse liability of nalmefene and the second will determine the efficacy of nalmefene to block the subjective and physiological effects of morphine. The first study has been completed. Results indicated that nalmefene did not produce typical opiate-like abuse liability, but that side effects, such as feelings of agitation and irritability, muscle tension, headache, and insomnia may limit its use as possible treatment for opioid dependence. The second study was recently completed, and the data are currently being analyzed. A preliminary report will be presented at the 1991 meeting of the Committee on Problems of Drug Dependence.