MAPPING THE EFFECTS OF OPIOID AGONISTS BY EEG

吗啡对头皮EEG和FDG PET扫描的影响正在进行比较 来确定兴奋时大脑的活动区域 收集的病因 过去几年，现在正在分析来自20个头皮位置的EEG数据， 接受安慰剂、15和30毫克吗啡注射的后成瘾者。 这些受试者随后接受FDG PET扫描，同时接受 安慰剂和30毫克吗啡 PET扫描由我们的 合作者 EEG数据本身提供了对时间进程的洞察 μ激动剂在人类和大脑皮层中的电生理作用 Mu效应的分布。PET技术本身并不提供 关于mu效应的时间过程的信息。 上对初级 分析中，12名受试者的EEG δ和θ功率增加， 从15分钟开始，持续到45分钟后， 肌肉注射 伪影检测的变化正在 研究了这些EEG变化与 可以研究吗啡的主观作用。

Effects of morphine on the scalp EEG and FDG PET scans are being compared to determine the brain areas invoked in euphoria. Etiology collected in past years and is now analyzing the EEG data from 20 scalp locations from post addicts receiving placebo, 15 and 30 mg injections of morphine. These subjects subsequently received FDG PET scans while receiving placebo and 30 mg of morphine. The PET scans are performed by our collaborators. The EEG data by itself provides insight into time course of electrophysiologic effects of a mu agonist in humans and the cortical distribution of mu effects. PET techniques do not by themselves provide information about the time course of the mu effects. In the preliminary analysis, twelve subjects had increased EEG delta and the theta power beginning 15 minutes and persisting until 45 minutes after the intramuscular injection. Changes in artifact detection were being investigated so that the relationship between these EEG changes and subjective effects of morphine can be investigated.