Defining the epigenetic origins of maternally inherited disease.

精子和卵子中DNA的表观遗传（非遗传）变化可以改变儿童的结局。尽管药物和饮食有可能调节这些遗传效应，但人们对其中的过程知之甚少。通过确定调节表观遗传的机制，该项目将提高我们对表观遗传机制如何在父母中起作用的理解，可以介导遗传性疾病和我们孩子的终身健康结果。

Epigenetic (non genetic) changes to the DNA in sperm and eggs can alter outcomes in children. Despite the potential for drugs and diet to mediate some of these inherited effects, the processes involved are very poorly understood. By determining the mechanisms that regulate epigenetic inheritance, this project will improve our understanding of how epigenetic mechanisms acting in the parent, can mediate inherited disease and life-long health outcomes in our children.