COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS

钙结合蛋白、钙滞留蛋白（钙视网膜蛋白- 免疫组化结果显示，在迷走神经和舌咽神经感觉细胞体中， 神经节（颈静脉、岩神经和结状神经节）和相关神经 纤维 在颈静脉和岩神经节， 降钙素基因相关肽和降钙素基因相关肽 P. 在结状神经节中，大多数calretininin-ir神经元缺乏这些 缩氨酸 虽然钙视网膜蛋白的功能尚不清楚，但其分布 表明在迷走神经和舌咽感觉系统中的作用。 从 颈静脉神经节、CGRP阳性神经元和SP阳性神经元向脑血投射 血管、甲状腺、气管、颈动脉窦和颈动脉体。 从 岩神经节、CGRP和SP神经元投射至颈动脉窦， 颈动脉体和味蕾 钙视网膜蛋白和这些蛋白的共存 一些颈静脉和许多岩神经元中的肽表明， 钙结合蛋白与来自大脑皮层的感觉传递有关， 颈动脉窦、颈动脉体和味蕾。 此外，我们还表明， 在舌头味蕾的神经纤维中发现了钙视网膜蛋白 和颈动脉体

Immunoreactivity for the calcium binding protein, calretenin (calretinin- ir), was demonstrated in cell bodies of vagal and glossophyrngeal sensory ganglia (jugular, petrosal, and nodose ganglia) and in associated nerve fibers. In the jugular and petrosal ganglia, many calretinin-ir neurons were also immunoreactive for calcitonin gene-related peptide and substance P. In the nodose ganglion, most of the calretinin-ir neurons lacked these peptides. While the function of calretinin is unclear, its distribution suggests a role in the vagal and glossopharyngeal sensory systems. From the jugular ganglion, CGRP-and SP-ir neurons project to cerebral blood vessels, thyroid gland, trachea, carotid sinus and carotid body. From the petrosal ganglion, CGRP and SP neurons project to the carotid sinus, carotid body and taste buds. The coexistence of calretinin and these peptides in some jugular and in many petrosal neurons suggests that this calcium binding protein is associated with sensory transmission from the carotid sinus, carotid body and taste buds. Furthermore, we have shown that calretinin is observed in nerve fibers in the taste buds of the tongue and in the carotid body.