CEREBRAL ISCHEMIA AND MONOAMINES

这项调查是一项持续的努力，以阐明 病理机制负责更大的易感性，成人比 年轻的动物脑缺血。 具体来说，这项研究是 与突触体5-羟色胺 （5-HT）释放和5-HT_2-（S_2）突触后的动力学特性 成年和幼年蒙古沙土鼠大脑皮层的受体 经受相同的缺血性损伤（双侧缺血[15分钟]， 且无再循环[60 min]）。 结果表明，突触体5-HT 5-HT 2-突触后释放（=突触前功能）和特性 受体在成年和幼年沙土鼠缺血中的作用。 只有增加 5-HT从突触体的释放调节了 5-HT 2-突触后受体。 这些发现还表明， 观察到成年沙鼠对脑缺血的敏感性比 年轻动物的大脑与它们独特的神经元 功能

This investigation represents a continuous effort to elucidate the pathomechanism responsible for the greater susceptibility of adult than young animals to cerebral ischemia. Specifically, this study was concerned with the relationship between synaptosomal 5-hydoxytryptamine (5-HT) release and the kinetic properties of 5-HT2- (S2) postsynaptic receptors in the cerebral cortex of adult and young Mongolian gerbils subjected to the same ischemic insult (bilateral ischemia [15 min] with and without recirculation [60 min]). The results show a close correlation between the synaptosomal 5-HT release (= presynaptic function) and properties of 5-HT2-postsynaptic receptors in ischemia of adult and young gerbils. Only the increased release of 5-HT from synaptosomes modulated the profile of 5-HT2-postsynaptic receptors. These findings also suggest that the observed greater susceptibility of adult gerbils to brain ischemia than that of the young animals is linked to their distinctive neuronal function.