CHARACTERIZATION OF THE WHHL RABBIT LIPOPROTEIN PHENOTYPES

兽医资源计划，国家研究资源中心， 已建立渡边遗传性高脂血症(WHHL)兔品种 殖民地作为调查人员的资源。Watanabe等人。据报道， 有两种类型的WHHL兔，一种是发育早期的兔，一种是高发育兔 冠状动脉粥样硬化(1型)和晚期冠状动脉粥样硬化症的发生率 发展和低发生率的冠状动脉粥样硬化(2型)。它有 还表明，无论哪种类型的兔子都可以有选择地繁殖以 产生表现出感兴趣表型的后代。最近，它是 报道称，这两种类型的WHHL兔可以通过 他们的脂蛋白表型。14只日本大耳白兔的电泳分析 NIH WHHL兔菌落显示有两种脂蛋白 表型：一种是β-脂蛋白密度增加，另一种是 穿着贝塔双人套装。这些表型与已报道的 两种类型的WHHL兔。

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators. Watanabe et al. reported that there are two types of WHHL rabbits, those with early development and high incidence of coronary atherosclerosis (type 1) and those with late development and low incidence of coronary atherosclerosis (type 2). It has also been shown that either type of rabbit can be selectively bred to produce progeny exhibiting the phenotype of interest. Recently, it was reported that these two types of WHHL rabbits can be differentiated by their lipoprotein phenotypes. Electrophoretic analysis of 14 rabbits from the NIH WHHL rabbit colony showed that there are two lipoprotein phenotypes: one with an increased density of beta-lipoprotein and another with a beta-doublet. These phenotypes are similar to those reported for the two types of WHHL rabbits.