Defining the genomic and therapeutic landscape of familial breast cancer
Defining the genomic and therapeutic landscape of familial breast cancer
批准号:
nhmrc : 1080985
负责人:
Dr Nicola Waddell
金额:
$76.42万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31
中文摘要
随着癌症的发展,它会在DNA中积累变化(突变)。其中一些改变导致肿瘤生长加快,而另一些则提供了对正常过程的了解,这些过程出现了问题,使肿瘤得以产生。我们将使用DNA测序和数学方法来表征这些改变,并确定具有遗传易感性的乳腺癌患者产生的乳腺肿瘤的治疗靶点。
英文摘要
As a cancer develops it accumulates alterations (mutations) in its DNA. Some of these alterations lead to enhanced tumour growth, whilst others provide insight into normal processes that have gone wrong to enable the tumour to arise. We will use DNA sequencing and mathematical approaches to characterise these alterations and to identify therapeutic targets in breast tumours arising in patients with an inherited predisposition to develop cancer.
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会议论文
Clinical application of genomic approaches for cancer
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批准号:nhmrc : GNT1139071
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项目类别:Research Fellowships
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资助金额:$70.74万
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财政年份:2018
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负责人:Dr Nicola Waddell
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依托单位:
Clinical application of genomic approaches for cancer
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批准号:nhmrc : 1139071
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项目类别:Research Fellowships
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资助金额:$47.83万
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财政年份:2018
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负责人:Dr Nicola Waddell
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依托单位:
Improving oesophageal adenocarcinoma outcomes through understanding genomics and treatment toxicity.
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批准号:nhmrc : 1147118
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项目类别:Project Grants
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资助金额:$67.57万
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财政年份:2018
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负责人:Dr Nicola Waddell
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依托单位:
Towards better treatments for acral melanoma through functional genomics
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批准号:nhmrc : 1123217
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项目类别:Project Grants
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资助金额:$98.9万
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财政年份:2017
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负责人:Dr Nicola Waddell
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依托单位:
Towards better treatments for acral melanoma through functional genomics
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批准号:nhmrc : GNT1123217
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项目类别:Project Grants
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资助金额:$145.68万
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财政年份:2017
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负责人:Dr Nicola Waddell
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依托单位:
Application of next generation sequencing to address clinical problems in cancer
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批准号:nhmrc : 1112113
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项目类别:Career Development Fellowships
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资助金额:$31.68万
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财政年份:2016
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负责人:Dr Nicola Waddell
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依托单位:
Application of next generation sequencing to address clinical problems in cancer
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批准号:nhmrc : GNT1112113
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项目类别:Career Development Fellowships
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资助金额:$30.92万
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财政年份:2016
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负责人:Dr Nicola Waddell
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依托单位:
Defining the genomic and therapeutic landscape of familial breast cancer
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批准号:nhmrc : GNT1080985
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项目类别:Project Grants
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资助金额:$111.5万
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财政年份:2015
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负责人:Dr Nicola Waddell
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依托单位:
Characterising the mutations, signatures, potential new therapeutic targets and biomarkers in malignant mesothelioma using whole genome analysis.
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批准号:nhmrc : GNT1089404
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项目类别:Project Grants
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资助金额:$118.85万
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财政年份:2015
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负责人:Dr Nicola Waddell
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依托单位:
Characterising the mutations, signatures, potential new therapeutic targets and biomarkers in malignant mesothelioma using whole genome analysis.
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批准号:nhmrc : 1089404
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项目类别:Project Grants
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资助金额:$81.3万
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财政年份:2015
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负责人:Dr Nicola Waddell
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依托单位:
国内基金
海外基金
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