HIGH RESOLUTION AND ROUTINE SERVICE MASS SPECTROMETERS

哈佛大学化学系为这项研究申请资金 购置了两台质谱仪。第一个将是一个 高性能、高分辨率电子碰撞质谱仪 (EI)、化学电离(CI)和快原子轰击(FAB) 电离能力；这台仪器将由训练有素的 操作员。第二个将是开放使用的通用工具 由所有符合条件的用户提供。由六名教员组成的核心小组和他们的研究 团队将使用这些新工具来表征复杂的有机物质 化合物。该小组进行的研究包括合成 生物活性物质(如前列腺素、白三烯、 血栓烷，血型物质，免疫刺激剂，抗生素， 抗病毒药物、多肽、糖、激素和核酸)和 天然产物和合成产物的结构测定 中间体。

The Department of Chemistry at Harvard University requests funds for the acquisition of two mass spectrometers. The first will be a high-performance, high-resolution mass spectrometer with electron impact (EI), chemical ionization, (CI) and fast atom bombardment (FAB) ionization capabilities; this instrument will be operated by trained operators. The second will be a general purpose instrument open to use by all qualified users. A core group of six faculty and their research teams will use these new instruments to characterize complex organic compounds. Research conducted by this group includes the synthesis of biologically active substances (such as prostaglandins, leukotrienes, thromboxanes, blood group substances, immunostimulators, antibiotics, antiviral agents, polypeptides, sugars, hormones and nucleic acids) and the determination of structures of natural products and synthetic intermediates.