PESTICIDE AND FERTILIZER MIXTURE STUDY

人类对化学品的接触很少局限于一种化学品。 最近对农业区地下水污染的担忧已经 领导NTP启动农药/化肥毒理学研究 基于确认的地下水污染的化学混合物 加利福尼亚州和爱荷华州。在进行长期毒性研究的同时 骨髓的合同、特异性骨髓毒性和后遗症 都被调查过。对暴露于空气中的小鼠的骨髓参数进行监测 0、1X、1OX和100X化学混合物II或III饮用水，用于3至 15周。部分小鼠在停药后恢复8周。 化学治疗，然后接受200拉德的全身照射，两次 每隔8周。同时进行血液学和组织病理学检查。 已执行。

Human exposure to chemicals is rarely limited to one single chemical. Recent concern about groundwater contamination in agricultural areas has led the NTP To initiate a study of the toxicology of pesticide/fertilizer chemical mixtures which are based on confirmed groundwater contamination in California and Iowa. While the long-term toxicity studies were being done on contract, specific myelotoxicity and residual effects of bone marrow were investigated. Bone marrow parameters were monitored in mice exposed to 0, 1X, 1OX, and 100X of chemical mixture II or III drinking water for 3 to 15 weeks. Some mice were allowed to recover for 8 weeks after cessation of chemical treatment, then Received whole body irradiation 200 rads twice at 8-week intervals. Examinations of hematology and histopathology were also performed.