NEURAL AND ENDOCRINE BASIS OS SELF-STIMULATION OF OVARIAN DEVELOPMENT/DOVES

先前的研究表明， 雌激素敏感丘间核（ICo）破坏 雌性巢啼和雄性求偶诱导卵巢发育 在戒指鸽子。 在这个建议中，我们分析了潜在的神经 电路和神经内分泌机制的方法， 电解损伤，选择性化学损伤，电生理学 记录和免疫组织化学。 三项相互关联的研究 本文提出：（1）研究ICo神经元的作用;（2）研究ICo神经元的作用; 端脑中心，如带核，雌激素 向ICO发送预测的敏感区域，以及（3）角色 下丘脑视前-前区的ICo投射， 促性腺激素释放激素集中的区域 神经元，相对于生产巢coo显示（声乐 和姿势成分）和卵巢对不同咕咕声的反应。 这些研究的长期目标是描绘神经和 行为介导的内分泌机制 卵巢活动 这些研究可能最终有助于 了解和控制众所周知的临床现象，如 提高妇女怀孕的机会， 领养一个

It has been shown in previous studies that electrolytic lesions in the estrogen-sensitive nucleus intercollicularis (ICo) disrupt female nest-coos and male courtship induced ovarian development in the ring dove. In this proposal we analyze the underlying neural circuitry and neuroendocrine mechanisms with the methods for electrolytic lesion, selective chemical lesion, electrophysiological recordings and immunohistochemistry. Three interrelated studies are proposed: (1) Study of the role of the ICo neurons, (2) Role of telencephalic centers, such as nucleus taenia, an estrogen sensitive region which sends projections to the ICo, and (3) Role of the ICo projections to pre-optic-anterior hypothalamic region, an area concentrated with gonadotrophin releasing hormone neurons, with respect to the production of nest-coo display (vocal and posture component) and ovarian response to different coos. The long-term goal of these studies is to delineate the neural and endocrine mechanisms underlying the behaviorally mediated ovarian activity. These lines of studies may eventually help to understand and control of well-known clinical phenomenon such as the promotion of a woman's chance to conceive a child by adopting one.