WHHL RAABBIT LIPOPROTEIN PHENOTYPES

兽医资源计划，国家研究资源中心， 已建立渡边遗传性高脂血症兔(WHHL)育种 作为调查人员的资源。Watanabe等人。有 报道称，有两种类型的WHHL兔；那些早期 冠状动脉粥样硬化症的发生和高发 发展较晚，冠状动脉粥样硬化发生率低。它有 已经证明，通过鉴定其中一种类型的WHHL兔，它可能是 有选择地繁殖以产生表现出特定表型的后代 利息。最近，有报道称，这两种类型的WHHL兔 可以通过它们的脂蛋白表型来区分。有一只白兔 冠状动脉粥样硬化的高发表现为脂蛋白表型 类似于III型高脂血症。 这项研究的目的是表征人的脂蛋白表型。 NI.H.WHHL兔群体，使这两种类型的WHHL兔可以 已确认身份。

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic rabbit (WHHL) breeding colony to be used as a resource for investigators. Watanabe et al. have reported that there are two types of WHHL rabbits; those with early development and high incidence of coronary atherosclerosis and those with late development and low incidence of coronary atherosclerosis. It has been shown that by identifying either type of WHHL rabbit it could be selectively bred to produce progeny exhibiting the particular phenotype of interest. Recently, it was reported that these two types of WHHL rabbits can be differentiated by their lipoprotein phenotypes. The rabbits with a high incidence of coronary atherosclerosis exhibit a lipoprotein phenotype similar to type III hyperlipidemia. The purpose to this study is to characterize the lipoprotein phenotypes in the N.I.H. WHHL rabbit colony so that the two types of WHHL rabbits can be identified.