STUDIES ON EPSTEIN-BARR VIRUS AND HIV

获得性免疫缺陷综合征B细胞淋巴瘤 发生在30岁年龄组的个人中，有 同性恋、双性恋和静脉注射毒品。三十 这些淋巴瘤中有百分之百的组织学上是Burkitt型，并且 含有爱泼斯坦-巴尔病毒(EBV)基因组。另一个B细胞 淋巴瘤是一种弥漫性的大细胞型，缺乏EBV。 协会。基于这些发现，EBV的相互作用， 可能是其他人类病毒，B细胞淋巴瘤中的艾滋病毒是 调查过了。 与EB病毒相关的B细胞淋巴瘤是在HIV病毒中发展起来的- 艾滋病患者6个月后出现阳性和抗体阳性 EB病毒早期抗原抗体(EA)效价显著升高 都观察到了。这提示EBV可能导致多克隆。 B细胞的增殖，其中一个可能会经历 转型。 在这些调查过程中，一种新的人类B 从外周血中分离出嗜淋巴细胞病毒(HBLV) 两例艾滋病B细胞淋巴瘤患者的淋巴细胞。 后来，从四名患有乙肝的患者身上也分离出了HBLV。 血管免疫母细胞性淋巴结病、免疫母细胞性淋巴瘤 和淋巴细胞白血病。HBLV是一种新的疱疹病毒 在基因和免疫上与已知截然不同 疱疹病毒。

Acquired immunodeficiency syndrome (AIDS) B-cell lymphomas occur in individuals in the 30-year age group with a history of homosexuality, bisexuality, and intravenous drug use. Thirty percent of these lymphomas are, histologically, Burkitt's type and contain the Epstein-Barr virus (EBV) genome. The other B-cell lymphomas are diffuse, large cell type which lack EBV association. Based on these findings, the interaction of EBV, possible other human viruses, and HIV in B-cell lymphomas was investigated. B-cell lymphomas associated with EBV developed in an HIV-virus- positive and antibody-positive AIDS patient six months after significant increase in EBV-early antigen antibody (EA) titers were observed. This suggested that EBV may lead to polyclonal proliferation of B-cells, one of which may undergo transformation. During the course of these investigations, a novel human B lymphotropic virus (HBLV) was isolated from peripheral blood lymphocytes from two AIDS patients with B-cell lymphomas. Later on, HBLV was also isolated from four patients with angioimmunoblastic lymphoadenopathy, immunoblastic lymphoma, and lymphocytic leukemia. HBLV is a new herpesvirus which is genetically and immunologically distinct from known herpesviruses.