IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS FOR BIOMEDICAL RESEARCH

我们正在开发铁-57和氘核磁 共振(核磁共振)作为一种实验方法用于 生物医学科学。在血液中发现了许多化合物 含有铁芯。其中包括细胞色素， 血红蛋白，或铁还蛋白。可以使用的化学方法很少 直接研究这些原子的中心金属原子环境 蛋白质。铁-57核磁共振就是为了这个目的而开发的。 一段时间前，我们报道了铁-57核磁共振在研究中的应用 某些铁化合物的驰豫时间和化学位移 与生物实体相关的。因此，我们确定了基本的 为进一步研究铁核磁共振所需的参数。 我们目前的努力是将这个项目扩展到包括 铁卟啉的场相关氢-2核磁共振研究 作为铁核磁共振的一种配套方法，导致了 铁卟啉表面各向异性的部分测量 在磁场中定向的。

We are developing iron-57 and deuterium Nuclear Magnetic Resonance (NMR) as an experimental method for use in the Biomedical Sciences. Many compounds found in the blood contain iron cores. Among these are the cytochromes, hemoglobin, or ferridoxin. Few chemical methods may be used to directly study the central metal atom environments of these proteins. Iron-57 NMR is being developed for that purpose. Some time ago, we reported the utility of iron-57 NMR for study of relaxation times and chemical shifts of some iron compounds related to biological entities. We determined thus the basic parameters needed for further study of iron NMR. Our current efforts to extend this project to include an examination of the field dependent H-2 NMR of iron porphyrins as a companion method to iron NMR have resulted in measurements of anisotropies on iron porphyrins partially oriented in a magnetic field.