RADIATION THERAPY WITH RADIOLABELLED ANTIBODIES--TECHNICAL ASPECTS AND DOSIMETRY

给药放射性标记抗体是一种相对较新的方法 治疗某些形式癌症的方式。其中很大一部分 田野在本质上是发展的。特别是在剂量学方面， 肿瘤肿块，特别是显微镜下的肿块，到目前为止 未知。辐射物理与计算机自动化 科室正在积极协助实施临床 协议。目前的研究主要集中在两个方面。图像的图像 特定器官在时间上的分布模式是 对于理解抗体动力学和 大体积辐射剂量学(在整个器官水平)。这个 能够使用以下工具精确定位生物分布模式 核医学成像技术与准确配准 这些图像与其他成像方式(CT或 磁共振成像)对于获得定量结果是必不可少的。另外， 最接近显微肿瘤肿块的剂量学方法。 通过使用计算机建模。结果，其中 可能，将使用定量放射自显影进行验证。

Administration of radiolabelled antibodies is a relatively new treatment modality for certain forms of cancer. Much of this field is developmental in nature. In particular, the dosimetry of tumor masses, especially at the microscopic level, is as yet unknown. The Radiation Physics and Computer Automation Section is actively assisting in the implementation of clinical protocols. Current research is in two major areas. Imaging of the organ-specific distribution patterns on a temporal basis is fundamental to the understanding of antibody kinetics and for large volume radiation dosimetry (at the total organ level). The ability to accurately localize biodistribution patterns using nuclear medicine imaging techniques and to accurately register these images with respect to other imaging modalities (CT or MRI) is essential for obtaining quantitative results. Additionally, the dosimetry of microscopic tumor masses is best approached through the use of computer modelling. The results, where possible, will be validated using quantitative autoradiography.