POST-ISCHEMIC ACCUMULATION OF CALCIUM IN BRAIN TISSUE AND ISCHEMIC INJURY

钙的地形和时间序列的观测 单次和反复脑缺血后的蓄积， 使用45-钙放射自显影，显示显著差异 在钙的出现模式中，在单一的 双侧颈动脉闭塞5分钟和随后的3个90分钟 第二次闭塞。我们的观察表明， 缺血后时期的钙不一定与 不可逆的缺血性损伤。此外，我们的发现 证明钙的积累可以发生在 神经元被完全摧毁的区域表明 钙的吸收可能包括一个重要的成分，在非 神经元素。鉴于被归因于 钙在缺血性损伤中的作用机制的进一步研究 受缺血影响的脑组织中的钙积累是 在目前的调查中。

Observations on the topography and the time sequences of calcium accumulation following single and repetitive cerebral ischemia, using 45-calcium radioautography, revealed significant differences in the pattern of calcium appearance between that seen in a single 5 minute bilateral carotid occlusion and that following three 90 second occlusions. Our observations indicate that accumulation of calcium during postischemic periods does not necessarily correlate with irreversible ischemic injury. Furthermore, our finding demonstrating that accumulation of calcium can take place in regions where the neurons were totally destroyed indicates that the uptake of calcium may include a significant component in non- neuronal elements. In view of the important role attributed to calcium in ischemic injury, further studies on mechanisms of calcium accumulation in ischemically affected brain tissue are under current investigation.