慢性中枢神经系统疾病研究——缓慢、潜伏和温带病毒感染-猫眼课题宝

慢性中枢神经系统疾病研究——缓慢、潜伏和温带病毒感染

批准号：

3922452

负责人：

D CARLETON GAJDUSEK

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3922452

关键词：

Alzheimer's disease Huntington's disease Parkinson's disease autoimmune disorder brain neoplasms central nervous system disorders chronic disease /disorder communicable disease transmission congenital neuromuscular disorder degenerative motor system disease dementia electrofocusing encephalitis genetic disorder human morbidity human population genetics human subject iatrogenic disease immunofluorescence technique in situ hybridization international cooperation latent virus infection multiple sclerosis muscular dystrophy myelinopathy nervous system disorder diagnosis nervous system disorder epidemiology nervous system infection neuromuscular disorder diagnosis neurotropic virus nucleic acid hybridization partial seizure progressive multifocal leukoencephalopathy scrapie serology /serodiagnosis spongiform encephalopathy subacute sclerosing panencephalitis virus antigen virus classification virus cytopathogenic effect virus infection mechanism virus replication zoonosis

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中文摘要

翻译

研究阐明了慢性退行性疾病的病因和发病机制

英文摘要

Studies elucidate cause and pathogenesis of chronic degenerative CNS disorders with emphasis on MS, ALS, Parkinsonism-dementia, Parkinson's, Pick's and Alzheimer's disease, Huntington's chorea, supranuclear palsy, other presenile dementias, spinocerebellar ataxias, epilepsy, chronic encephalitis with focal epilepsy, muscular dystrophies, chronic schizophrenia, autism, SSPE, PML, dialysis encephalopathy, and intracranial neoplasm. Even familial, apparently hereditary diseases may be slow virus infections. Subacute spongiform virus encephalopathies: kuru and Creutzfeldt- Jakob disease (CJD) of man; scrapie and mink encephalopathy are caused by unconventional viruses with unique properties posing important theoretical problems to microbiology and molecular biology; a major goal is elucidation of their structure and mechanisms of replication. Transmissible virus dementias are increasingly recognized worldwide causes of death: high incidence foci, transmission by corneal transplant or brain surgery, and occupational hazards from exposure to diseased or infectious brain. In order to determine the usual mode of infection with the virus, a worldwide epidemiological study of transmissible virus dementia (CJD) cases is underway with special attention to familial clusters of cases and with a quest for possible relationship of scrapie of sheep to the human disease. Familial and nonfamilial dementia and the dementias of senility are studied. The autoimmune responses to specific brain antigens in CNS diseases are under intensive investigation. DNA in situ hybridization and electrophoretic focusing partition of proteins along with enzymatic and hybridoma immunofluorescence and many other techniques are- used to try to identify viral subunits and partial genomes in tissues in chronic diseases.

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