TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CLOMIPRAMINE

强迫症（OCD）现在被认为是一种 一种常见的精神疾病， 在这个国家的人。 在青少年中， 可能高达百分之一。 本处分支的跟进研究显示， 抑郁症和焦虑症的严重程度不断增加， 时间 氯丙咪嗪具有高度特异性的有益效果， 而去甲丙咪嗪（Desmethylimipramine，简称DMM）是另一种三环 抗抑郁药与安慰剂没有差异。 脑成像（PET和CT扫描）的新研究，以及 西德纳姆舞蹈病患者的调查， 基底神经节异常而脊髓液研究显示 脑脊液中5-HIAA的低浓度， 代谢物，与更严重的强迫症有关。

Obsessive Compulsive Disorder (OCD) is now recognized as a common mental disorder, occurring in perhaps three million people in this country alone. In adolescents, the prevalence maybe as high as one percent. Follow-up studies in our Branch show a chronic course for the disorder with increasing severity of depression and anxiety over time. Clomipramine has a highly specific beneficial effect on obsessions while Desmethylimipramine (DMI) another tricyclic antidepressant did not differ from placebo. New studies with brain imaging (PET and CT scan), as well as a survey of patients with Sydenham's chorea, implicate abnormalities in the basal ganglia while spinal fluid studies show that low concentration of CSF 5-HIAA, the major serotonin metabolite, is associated with more severe OCD.