ANALYSIS OF SUDDEN INFANT DEATH SYNDROME (SIDS) RISK FACTORS

NICHD合作小岛屿发展中国家研究旨在使 识别可区分小岛屿发展中国家的危险因素 来自非小岛屿发展中国家的婴儿。该设计是一种 多中心、以人群为基础的病例对照研究 在838例小岛屿发展中国家中(800例单胎和38例多胎) 是根据共同验尸协议确定的。当时有1600人 配对的独生子女对照婴儿和40例共生婴儿 对照组婴儿被招募到研究中。这是最大的详细信息 曾经进行过小岛屿发展中国家的流行病学研究。数据是 为15个月内死亡的婴儿收集的 1978年10月至1979年12月。每一个婴儿的死亡都是 根据常见的组织切片进行了尸检 由三个小岛屿发展中国家组成的小组保存以供详细检查 病理学专家。根据与美国政府签署的机构间协议 武装部队病理研究所(AFIP)，技术支持是 为编制小岛屿发展中国家组织病理学地图集提供经费 用于实践教育的“学习集” 法医病理学家或病理学专业的学生。 在另一项小岛屿发展中国家风险因素研究中，时间序列技术 分析正在被用来检查潜在的异常 神经生理和心肺控制的研究进展 在生命的前三个月。学习材料 由来自长期的计算机化数据集组成 三个早期小儿麻痹症婴儿的电生理记录 研究性研究。下面将对以下内容进行比较 婴儿分组：小岛屿发展中国家婴儿的后续兄弟姐妹，“险些失手” 婴儿、双胞胎、配对对照组和后来死于 小岛屿发展中国家。

The NICHD Cooperative SIDS Study was designed to enable identification of risk factors which could differentiate SIDS infants from non-SIDS infants. The design is that of a multicenter, population-based, case-control study with a sample of 838 SIDS cases (800 singleton and 38 multiple birth SIDS cases) ascertained under a common necropsy protocol. There were 1,600 matched living singleton control infants and 40 co-multiple birth control infants recruited into the study. It is the largest detailed epidemiological study of SIDS ever undertaken. Data were collected for babies who died over a 15-month period from October, 1978 through December, 1979. Every infant death was autopsied in accordance with a common slides of tissues were preserved for detailed examination by a panel of three SIDS pathology experts. Under an Inter Agency Agreement with the Armed Forces Institute of Pathology (AFIP), technical support is being provided for the preparation of a SIDS Histopathology Atlas and "study sets" to be used for the education of practicing forensic pathologists or pathology students. In another SIDS risk factor study, techniques of time series analysis are being used to examine potential abnormalities in the development of neuro-physiological and cardio-respiratory control mechanisms in the first three months of life. The study materials consist of computerized data sets from long-term electrophysiological recordings of infants from three earlier SIDS research studies. Comparisons will be made among the following groups of infants: subsequent siblings of SIDS infants, "near-miss" infants, twins, matched controls, and infants who later died of SIDS.