MODELS IN THE MONKEY OF GENERALIZED SEIZURES OF THE ABSENCE TYPE

全身性癫痫活动伴电图表现 失神癫痫（双侧对称和同步 阵发性每秒三次尖峰和波放电）， 通过各种方法在猴子身上激发。 这些包括 对大脑内不同位置的电刺激， 注射致惊厥药物和其他物质，以及 给药可改变正常抑制性的化合物 细胞内的机制。 创建的模型癫痫发作状态 研究这些方法是为了检验关于 病理生理癫痫发作机制，感觉处理和 注意力的能力，在失神发作，影响的尖峰， 波活动对细胞活动的影响，以及技术或 可能改变或减少抽搐活动的动作。 最近，该项目涉及以下工作：我们 研究了GABA的行为和电图效应， 增强子，并调查了额叶注意相关细胞 猴子的叶子 其他关于“注意力”细胞的研究 下顶叶和前枕叶皮层已经完成， 好.

Generalized seizure activity with the electrographic appearance of absence epilepsy (bilaterally symmetrical and synchronous paroxysmal three-per-second spike and wave discharges) can be elicited in the monkey by a variety of methods. These include electrical stimulation of various locations within the brain, injection of convulsant drugs and other substances, and administration of compounds which may alter normal inhibitory mechanisms within the cell. Model seizure states created in these ways are studied in order to test hypotheses about pathophysiological seizure mechanisms, sensory processing and attentional capacities during absence seizures, effects of spike- wave activity on cellular activity, and effects of techniques or maneuvers which may modify or reduce convulsive activity. Most recently this project has involved the following work: we studied the behavioral and electrographic effects of a GABA- enhancer and surveyed the attention-related cells in the frontal lobes of the monkey. Other studies of "attention" cells in inferior parietal and preoccipital cortex have been completed as well.