MATERNAL INFECTION STUDY

围产期合作项目(CPP)数据分析 在产妇感染方面仍在继续。(CPP是一项 对大约60,000名孕妇和 对他们的孩子进行跟踪，直到他们生命的第七年。)二 使用了主要的方法，一个前瞻性的和一个案例的 控制进场。因为所有的血清学确认都是 年所有妇女在怀孕期间发生的常见感染 这个项目是不可行的，病例对照设计 已经实施了对女性11种抗原效价的评估 与对照组相比，有异常儿童的 孩子正常的女人。这项研究没有显示出任何明确的 第二、三期感染的相关性研究 怀孕三个月和对孩子的具体损害。一个 儿童发病率与儿童疾病关系的前瞻性研究 弓形虫病母源抗体水平及描述性研究 滴度的分布和血清转换的频率 不同抗原孕鼠的种族和年龄分布 怀孕妇女，正在进行或已经完成。这个 弓形虫病及其相关性的前瞻性血清学研究 怀孕结果，基于#年的前23,000例怀孕 这项研究表明，患耳聋的风险增加， 高智商妇女所生子女中的小头畸形和低智商 弓形虫病母源抗体。报道这一事件的手稿 弓形虫病研究和血清学研究结果 已提交确认感染病例以供公布。

Analysis of the Collaborative Perinatal Project (CPP) data continues in the area of maternal infection. (The CPP is a prospective study of approximately 60,000 gravidae and the follow-up of their children through the seventh year of life.) Two primary methodologies have been used, a prospective and a case control approach. Since serological confirmation of all of the common infections occurring during pregnancy on all women in the project would not have been feasible, a case control design has been implemented assessing the titer of 11 antigens in women with abnormal children, in comparison with matched control women with normal children. This study did not show any clear association between infection during the second and third trimester of pregnancy and specific damage to the child. A prospective study of the association of childhood morbidity with maternal antibody level to toxoplasmosis and a descriptive study of the distribution of titers and frequency of seroconversions by race and age of gravidae for various antigens in a population of pregnant women, are in progress or have been completed. The prospective serological study of toxoplasmosis and its relationship with pregnancy outcome, based on the first 23,000 pregnancies in the study, has shown increases in the risk of deafness, microcephaly and low IQ among children born to women with high maternal antibody to toxoplasmosis. Manuscripts reporting the results of the toxoplasmosis study and the study of serologically confirmed infections have been submitted for publication.