MONOCLONAL ANTIBODIES TO EWING'S SACOMA

这是一个新项目，刚刚开始。关于尤因的广泛研究 儿童肉瘤和相关的圆形细胞肿瘤有助于 根据与…的积极反应性将大多数区分开来 一种或多种抗体。没有针对尤文肉瘤的特异性抗体，或者 仅限于包括尤文氏症在内的几种肿瘤，迄今已被确认。 本研究的目的是生产一种单克隆化电池 针对选定的、特征良好的尤文肉瘤株的抗体 在这个实验室建立的。然后将对它们进行研究和比较 它们与先前报道过的其他单抗的反应性。任何 与尤文肉瘤细胞发生强反应的抗体将被 进一步的特征，最终打算将其用作 潜在的诊断、成像和治疗工具。

This is a new project, just commencing. Extensive studies of Ewing's sarcoma and related round cell tumors of childhood have served to distinguish most from one another on the basis of positive reactivity with one or more antibodies. No antibody specific for Ewing's sarcoma, or restricted to a few tumors including Ewing's, has been identified to date. It is the aim of the present study to produce a battery of monoclonal antibodies against selected, well-characterized Ewing's sarcoma lines established in this laboratory. They will then be studied and compared in their reactivity with other monoclonal antibodies previously reported. Any antibody found to be strongly reactive with Ewing's sarcoma cells will be further characterized, with the eventual intention to use same as a potential diagnostic, imaging, and therapeutic tool.