THERAPEUTIC STUDIES IN MURINE LUPUS

富含多不饱和脂肪酸二十碳五烯酸的饮食， 显著延缓(NZB×NZW)Fl的自身免疫进展 女性。即使在疾病发作之后，这也是有效的。人体试验是 正在执行中。 环磷酰胺是治疗多种自身免疫性菌株的有效药物 与疾病的细胞基础或其性质(B或T细胞)无关 正在增殖的细胞。这种疗法对治疗高血压病有效 MRL-LPR/LPR和C3H/HeJ-GLD/GLD小鼠的淋巴病变与冠状动脉 BXSB和(NZW×BXSB)F1小鼠的动脉疾病和肾脏疾病 大多数小鼠狼疮的例子。环磷酰胺显著降低了 MYB RNA在MRL-LPR/LPR小鼠淋巴结中的升高和极低水平的增加 胸腺MYB的表达。 环孢素A是一种干扰T细胞功能的药物，它是有效的 关节炎、肾炎、淋巴组织增生症的治疗 MRL-lpr/lpr小鼠。

A diet enriched in a polyunsaturated fatty acid, eicosapentaenoic acid, markedly retards the development of autoimmunity in (NZB x NZW) Fl females. This works even after the onset of disease. Human trials are being carried out. Cyclophosphamide is effective treatment in a variety of autoimmune strains unrelated to the cellular basis of illness or the nature (B or T cell) of the proliferating cells. This therapy is effective against the lymphadenopathy of MRL-lpr/lpr and C3H/HeJ-gld/gld mice and the coronary artery disease of BXSB and (NZW x BXSB)F1 mice as well as the renal disease of most examples of murine lupus. Cyclophosphamide markedly reduces the elevated myb RNA in MRL-lpr/lpr mice lymph nodes and increases the very low thymic myb expression. Cyclosporin A, a drug which interferes with T cell function, is effective treatment for the arthritis, nephritis, and lymphoproliferation of MRL-lpr/lpr mice.