BIOSYNTHESIS AND GLYCOSYLATION OF THYROTROPIN

促甲状腺激素的生物合成和碳水化合物的加工已经在 在各种生理条件和各种碳水化合物存在下 加工抑制剂 脱氧野尻霉素，抑制葡萄糖苷酶作用 并导致葡萄糖基化前体的积累，引起对 促甲状腺激素分泌，但对非糖蛋白分泌无影响 荷尔蒙 甲状腺激素和促甲状腺激素释放激素（TRH）引起 对促甲状腺素脱辅基蛋白和碳水化合物合成的不同影响 和分泌物。 TSH碳水化合物结构是异质的， 促甲状腺激素释放激素引起合成的特异性增加， 分泌双触角复合体形式。 浸润性 促甲状腺激素分泌型垂体瘤可分泌TSH， 碳水化合物结构 TSH的碳水化合物结构发生变化， 新生儿发育，并改变了室旁核病变， 引起下丘脑甲状腺功能减退的老鼠 TRH对TSH的影响 碳水化合物结构是特异性的，而不是由非特异性诱导的 促分泌素如钾。

Thyrotropin biosynthesis and carbohydrate processing has been studied under various physiologic conditions and in the presence of various carbohydrate processing inhibitors. Deoxynojirimycin, which inhibits glucosidase action and leads to accumulation of glucosylated precursors, caused inhibition of thyrotropin secretion but no effects on the secretion of nonglycoprotein hormones. Thyroid hormone and thyrotropin-releasing hormone (TRH) caused differential effects on thyrotropin apoprotein and carbohydrate synthesis and secretion. TSH carbohydrate structure is heterogeneous, and thyrotropin-releasing hormone caused a specific increase in synthesis and secretion of biantennary complex forms. Patients with invasive thyrotropin-secreting pituitary tumors may secrete TSH with more branched carbohydrate structure. The carbohydrate structure of TSH changes during neonatal development and is altered by paraventricular nuclear lesions in rats causing hypothalamic hypothyroidism. The effects of TRH on TSH carbohydrate structure are specific and not induced by non-specific secretagogues such as potassium.