眼神经胶质细胞参与葡萄膜炎的研究-猫眼课题宝

眼神经胶质细胞参与葡萄膜炎的研究

批准号：

3965399

负责人：

F ROBERGE

金额：

$0.0万

依托单位：

NATIONAL EYE INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3965399

关键词：

T lymphocyte cell cell interaction cellular pathology glia helper T lymphocyte immunopathology immunopharmacology inflammation retina surface antigens tissue /cell culture uvea uveitis

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中文摘要

翻译

这项工作涉及视网膜炎性疾病的机制。这项研究

英文摘要

The work concerns uveoretinal inflammatory disease mechanisms. The study focused on evaluating the role of resident cells at the target organ level. Muller cells interactions with T-lymphocyte cell line was studied in vitro. Two opposite effects of Muller cells on T-lymphocytes proliferation were found that could be expressed under different culture conditions. An inhibitory effect on antigen driven poliferation of T-helper lymphocytes could be modulated with various drugs that allowed the Muller cells to function as antigen presenting cells.

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