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LOCALIZATION AND CHARACTERIZATION OF BRAIN NEUROPEPTIDES

LOCALIZATION AND CHARACTERIZATION OF BRAIN NEUROPEPTIDES
脑神经肽的定位和表征
批准号：
3968427
负责人：
D M JACOBOWITZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968427
关键词：
atrial natriuretic peptide brain mapping central nervous system corticotropin releasing factor dissection high performance liquid chromatography hormone regulation /control mechanism immunochemistry melanocyte stimulating hormone neuroanatomy neurochemistry neuroendocrine system norepinephrine peripheral nervous system radioimmunoassay stereotaxic techniques

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中文摘要
翻译
(1)用放射免疫分析(RIA)和微穿孔技术定量 脑神经肽心钠素(ANF)和心钠素的分布 测定各脑核中甘丙素(Galanin，GAL)含量。广为流传 这些多肽在大鼠中枢神经系统的分布表明， GAL和ANF具有多种脑功能。(2)放射自显影 已证实半乳糖受体在大鼠脑内的分布。 (3)心钠素、半乳糖和降钙素的免疫组织化学分布 基因相关肽(CGRP)已被定位于人卵巢癌组织中的亚核。 脚间核。这项工作为进一步研究奠定了基础 脑神经肽(心钠素、半乳糖、降钙素基因相关肽)在脑缺血再灌注损伤中的作用 中枢神经系统。
英文摘要
(1) Using radioimmunoassay (RIA) and the micropunch technique quantitative distribution of the brain neuropeptides atrial natriuretic factor (ANF) and galanin (GAL) in discrete brain nuclei were determined. The widespread distribution of these peptides in the rat CNS suggests an involvement of GAL and ANF in a variety of brain functions. (2) The autoradiographic distribution of GAL receptor sites in the rat brain has been demonstrated. (3) The immunohistochemical distribution of ANF, GAL and calcitonin gene-related peptide (CGRP) has been mapped in the subnuclei of the interpeduncular nuclei. This work lays the groundwork for further studies on the functional role of these brain neuropeptides (ANF, GAL, CGRP) in the CNS.
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