The contribution of amyloid angiopathy to intracerebral haemorrhage: a clinico-radio-pathological case-control study

大约六分之一的中风是由于出血进入大脑。英国每年约有10，000名成年人遭受这种出血，其影响可能是毁灭性的。50%的患者在第一个月内死亡，而那些存活下来的患者功能明显受损;他们的生活质量受到严重影响。我试图了解更多关于一个条件，通常可能会导致这种出血。它被称为大脑淀粉样血管病（CAA）。它的发生是因为身体在大脑血管中沉积了一种叫做淀粉样蛋白的异常蛋白质。CAA被认为会导致大脑表面附近的出血，而其他情况（如高血压）被认为会导致大脑深处的出血。该项目旨在测试这些假设，看看大脑成像是否可以帮助检测CAA。在未来，这可能有助于在出血发生之前检测和治疗CAA。我将比较死于这种出血的人与死于其他原因的人的成像和脑组织样本。我希望这项工作将有助于医生制定一个更合理和有效的方法来管理这种毁灭性的条件。

About one in six strokes are due to bleeding into the brain. Around 10,000 adults in the UK suffer such a bleed annually and the effects can be devastating. 50% of patients die within the first month, and those that survive are significantly functionally impaired; their quality of life is badly affected. I seek to understand more about a condition that may commonly cause such bleeding. It is called cerebral amyloid angiopathy (CAA). It occurs because the body deposits an abnormal protein called amyloid in the blood vessels of the brain. CAA is thought to cause bleeds which occur near the surface of the brain, whereas other conditions (such as high blood pressure) are assumed to cause bleeding deep within the brain. This project seeks to test these assumptions and see if brain imaging can help detect CAA. In the future, this might help to detect and treat CAA before a bleed occurs. I will compare imaging and brain tissue samples of people who have died from such bleeds with people who have died from other causes. I hope this work will help doctors to develop a more rational and effective approach to managing this devastating condition.