Sudden Death Brain and Tissue Bank

科学研究的最终目的是改善公众的健康和福祉。为了实现这一目标，我们需要了解疾病的机制，以便我们可以尝试开发新的治疗方法。特别是神经系统疾病不仅对个人而且对护理人员造成相当大的痛苦。为了更好地理解疾病过程，需要研究动物模型，试图找出疾病的机制，然后将这些机制转化为人类环境。正是在这个翻译中，收集的人类材料，在尸检中获得的近亲的完全同意，是无价的。正是通过捐赠组织进行科学研究，一些护理人员才能够实现内心的平静，因为家庭成员的死亡可能会带来一些好处。多年来，人们一直从痴呆症和多发性硬化症等长期神经系统疾病的病例中收集脑组织。在突然死亡的情况下，由于死亡的意外性以及通常由于所涉及的个人的年轻，丧亲之痛往往会更加强烈，捐赠组织用于科学研究以前不是近亲的选择。MRC猝死脑和组织库提供了这个机会。虽然许多突然死亡的人在死亡时可能没有神经系统疾病，但与患有神经系统疾病的人的大脑相比，他们的组织可以提供有价值的信息。正常脑组织的这种控制功能对于所有脑疾病的研究都是必不可少的，并且与从脑疾病中获取组织一样重要。

Scientific research ultimately aims to improve the health and wellbeing of the public. To achieve this we need to understand the mechanisms of disease such that we may try to develop new treatments. Diseases of the nervous system in particular cause considerable suffering not just to the individual but also to the carers. To better understand disease processes requires the study of animal models, to try and work out the mechanisms of a disease, and then translation of these mechanisms to the human setting. It is in this translation that collected human material, obtained at autopsy with the full consent of the next of kin, is invaluable. It is through the donation of tissues to scientific research that some carers are able to achieve peace of mind that some good may come from the death of a family member. Brain tissue has been collected for many years from cases of long-term neurological diseases such as dementia and multiple sclerosis. In the setting of sudden death, where the bereavement is often felt more acutely due to the unexpectedness of the death and often due to the young age of the individuals involved, donating tissues to scientific research has previously not been an option available to the next of kin. The MRC sudden death brain and tissue bank provides this opportunity. Although many individuals dying suddenly may have no neurological disease at the time of death, their tissues can provide valuable information when compared to brain of an individual with established neurological disease. This control function of normal brain tissue is essential to investigation of all brain disorders and is as important as getting access to tissue from brain disorders.