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PROSTAGLANDIN RECEPTORS IN CULTURED GLIA AND CEREBROMICROVASCULAR SMOOTH MUSCLE

PROSTAGLANDIN RECEPTORS IN CULTURED GLIA AND CEREBROMICROVASCULAR SMOOTH MUSCLE
培养的神经胶质细胞和脑微血管平滑肌中的前列腺素受体
批准号：
3968950
负责人：
M SPATZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968950
关键词：
adenylate cyclase arachidonate blood brain barrier blood pressure brain circulation cerebral cortex cerebrovascular system cyclic AMP electron microscopy fatty acid biosynthesis fluorescence glia histochemistry /cytochemistry microcirculation microscopy organ culture prostaglandin E prostaglandin F prostaglandins radioimmunoassay vascular endothelium vascular endothelium permeability vascular smooth muscle

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中文摘要
翻译
前列腺素(PGE1、PGE2、PGF1α、PGF2Alpha、PGD2)对血管紧张素转换酶的影响 脑微血管内皮细胞腺苷环化酶(AC)的研究 肌肉和神经胶质细胞培养。PGE1和PGE2，而不是PGF1和 PGF2刺激两种细胞cAMP的形成。肌肉型AC 系统对E-型前列腺素的亲和力强于AC 神经胶质细胞中的系统。最重要的是，一种剂量依赖的PGI2，但不是 PGD2促进cAMP的形成，表现在血管内皮细胞。 在神经胶质细胞中可见PGI2和PGD2的反向AC反应。这些 结果表明，与AC相关的前列腺素受体是 每种细胞类型都是不同的。
英文摘要
The effect of prostaglandins (PGE1, PGE2, PGF1Alpha, PGF2Alpha, PGD2) on adenylate cyclase (AC) was investigated in cerebromicrovascular smooth muscle and glial cell cultures. PGE1 and PGE2, in contrast to PGF1 and PGF2, stimulated cAMP formation in both cell types. The smooth muscle AC system showed a greater affinity for E-type prostaglandins than the AC system in glial cells. Most importantly, a dose-dependent PGI2, but not PGD2 enhancement of cAMP formation, was manifested in smooth muscle while a reverse AC reactivity of PGI2 and PGD2 was seen in glial cells. These findings indicate that the prostaglandin receptors linked to AC are distinct in each cell type.
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会议论文
CEREBRAL ISCHEMIA--ENDOTHELIN-1 AND NITRIC OXIDE
ISCHEMIC BRAIN EDEMA--EFFECT OF Y-HYDROXYBUTYRATE ON S2-RECEPTOR BINDING SITES
INVESTIGATION OF EXTRANEURONAL CATECHOL SYNTHESIZING ENZYMES IN THE CNS
THE ESTABLISHMENT OF CEREBROVASCULAR SMOOTH MUSCLE CULTURE
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