CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS

研究阐明了慢性退行性CNS的原因和发病机制 重点是MS、ALS、帕金森氏症-痴呆、帕金森氏症， 皮克氏症，老年痴呆症，亨廷顿舞蹈症，核上性麻痹， 其他早老性痴呆、脊髓小脑共济失调、癫痫、慢性 脑炎伴局灶性癫痫、慢性肌营养不良 精神分裂症、自闭症、SSPE、PML、透析性脑病和颅内出血 肿瘤。 即使是家族性的、明显遗传的疾病也可能是慢性病毒性的 感染. 亚急性海绵状病毒脑病：库鲁病和 克雅氏病（Creutzfeldt-Jakob disease，CJD），羊瘙痒病和水貂脑病， 由具有独特特性的非常规病毒引起， 微生物学和分子生物学的理论问题;一个主要目标是 阐明其结构和复制机制。 传染性病毒性痴呆是越来越多的全球公认的原因 死亡率：高发病率病灶，通过角膜移植或大脑传播 外科手术和接触疾病或传染病的职业危害 个脑袋 为了确定病毒感染的通常模式， 传染性病毒性痴呆（CJD）病例的全球流行病学研究 正在进行中，特别关注家庭聚集性病例， 探索羊瘙痒病与人类疾病的可能关系。 家族性和非家族性痴呆以及老年痴呆是 研究了 中枢神经系统对脑特异性抗原的自身免疫反应 疾病正在进行深入调查。 DNA原位杂交和 蛋白质的电泳聚焦分配沿着与酶和 杂交瘤免疫荧光和许多其它技术被用于尝试 鉴定慢性疾病组织中病毒亚单位和部分基因组。

Studies elucidate cause and pathogenesis of chronic degenerative CNS disorders with emphasis on MS, ALS, Parkinsonism-dementia, Parkinson's, Pick's, and Alzheimer's disease, Huntington's chorea, supranuclear palsy, other presenile dementias, spinocerebellar ataxias, epilepsy, chronic encephalitis with focal epilepsy, muscular dystrophies, chronic schizophrenia, autism, SSPE, PML, dialysis encephalopathy, and intracranial neoplasm. Even familial, apparently hereditary diseases may be slow virus infections. Subacute spongiform virus encephalopathies: kuru and Creutzfeldt-Jakob disease (CJD) of man; scrapie and mink encephalopathy are caused by unconventional viruses with unique properties posing important theoretical problems to microbiology and molecular biology; a major goal is elucidation of their structure and mechanisms of replication. Transmissible virus dementias are increasingly recognized worldwide causes of death: high incidence foci, transmission by corneal transplant or brain surgery, and occupational hazards from exposure to diseased or infectious brain. In order to determine the usual mode of infection with the virus, a worldwide epidemiological study of transmissible virus dementia (CJD) cases is underway with special attention to familial clusters of cases and with a quest for possible relationship of scrapie of sheep to the human disease. Familial and nonfamilial dementia and the dementias of senility are studied. The autoimmune responses to specific brain antigens in CNS diseases are under intensive investigation. DNA in situ hybridization and electrophoretic focusing partition of proteins along with enzymatic and hybridoma immunofluorescence and many other techniques are used to try to identify viral subunits and partial genomes in tissues in chronic diseases.