RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

不同类型狼疮的发病机制 肾炎正在调查中。肾活检的详细分析 正在对系统性红斑狼疮患者的标本进行病理学检查 红斑狼疮。活检按狼疮的主要类别进行分类。 肾炎，以及对特定疾病的半定量评分 组织学变化表明活动程度和慢性 硬化症的特征。免疫复合体的沉积模式和 淋巴样细胞与肾单位不同节段的相互作用 通过免疫组织学技术和电子显微镜进行研究。这些 各种方法促进了对各种类型的 用于阻止狼疮性肾炎进展的免疫抑制剂 它们将加深我们对这一疾病的发病机制的理解 疾病。

The pathogenetic mechanisms underlying the different forms of lupus nephritis are being investigated. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by major category of lupus nephritis, as well as scored on a semiquantitative scale for specific histologic changes indicating the degree of activity and of chronic sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of this disease.