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MECHANISM OF HISTAMINE RELEASE

MECHANISM OF HISTAMINE RELEASE
组胺释放机制
批准号:
4692589
负责人:
R SIRAGANIAN
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
肥大细胞和血液嗜碱性粒细胞释放组胺的研究, 炎症的免疫机制之一。 也是一 细胞分泌的模型。 在所使用的组胺释放剂中, 是IgE抗体、过敏毒素、LHRH肽和Ca2+离子载体 A23187。 使用培养的大鼠嗜碱性白血病细胞作为模型, IgE受体与细胞内生化变化的研究 activation. 可以获得大量的细胞用于生化研究 和生物化学变体已经被选择, 细胞活化和分泌途径中的不同位点。
英文摘要
Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, the anaphylatoxins, LHRH peptides, and the Ca2+ ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
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