Physiopathology of brain-wide assemblies in adaptive memory

做决定时，我们常常借鉴以往的经验。这种从记忆中获取行为信息的能力依赖于大脑中神经细胞之间活动的精细协调。海马体是哺乳动物大脑的一个区域，这种“细胞集合”的活动与记忆引导的行为有关。然而，重要生活事件的记忆被认为跨越多个大脑区域，每个区域处理一个特定的信息维度。这种信息表示的组织可能是与自然衰老和某些神经/精神疾病相关的认知障碍复杂性的核心。在这里，我们将首先寻求提供一个全面的机制解释如何细胞活动分布在多个大脑区域支持复杂的，细节丰富的记忆。在这项工作中，我们将进一步考虑与药物滥用相关的不需要的记忆，这些记忆是适应不良反应的基础，研究跨脑区域的交流如何推动行为上消失的药物记忆的重新出现。我们将最终确定推理推理的大脑机制，这是一种高阶操作，允许个人推断出没有一起经历过的信息集之间的逻辑联系。本工作旨在提供干预的原则，以利用脑生理病理的适应不良的记忆。

When making decisions, we often draw on previous experience. This ability to inform behaviour from memory relies on the fine-grained coordination of activity between nerve cells in the brain. The hippocampus is a region of the mammalian brain where the activity of such “cell assemblies” has been related to memory-guided behaviour. However, memories of important life events are expected to span multiple brain regions, with each region processing a particular dimension of information. This organisation of information representation could be at the heart of the complexity of the cognitive disabilities associated with natural ageing and certain neurological/psychiatric diseases. Here, we will first seek to provide a comprehensive mechanistic explanation of how cell activities distributed across multiple brain regions support complex, detail-rich memories. In this work, we will further consider unwanted memories related to drugs of abuse that underpin maladaptive responses, investigating how cross-brain-region communication drives the re-emergence of behaviourally-extinguished drug memory. We will finally identify brain mechanisms of inferential reasoning, a higher-order operation that allows individuals to deduce logical links between sets of information that have not been experienced together. This work is intended to provide principles of interventions to harness brain physiopathology of maladaptive memory.