APPLICATIONS OF NEW MASS SPECTRAL TECHNIQUES

本项目的目标是研究和开发新的大众汽车 光谱技术，以便提供创新的和/或更快的 解决涉及(1)化学结构测定的问题，(2) 复杂混合物分析和(3)痕量成分的测定 生物系统。串联电喷雾电离质谱仪 质谱学和液-质联用 是当前人们感兴趣的技术。快速而灵敏的分析 在线高效液相色谱-电喷雾电离联用方法 串联质谱仪已被开发用于检测I相反 艾滋病临床候选药物2‘-β-氟-2’，3‘-二脱氧腺苷在人体内的分布 血浆。快原子轰击质谱仪已被用于 一系列羟基化芳香族化合物的结构表征 HIV-1整合酶抑制剂。

The objective of this project is research on and development of new mass spectral techniques in order to provide innovative and/or more rapid solutions to problems involving (1) chemical structure determination, (2) complex mixture analysis and (3) measurement of trace components in biological systems. Electrospray ionization mass spectrometry, tandem mass spectrometry and combined liquid chromatography-mass spectrometry are the techniques of current interest. A rapid and sensitive analytical method utilizing on-line liquid chromatography-electrospray ionization- tandem mass spectrometry has been developed to measure the Phase I anti- AIDS clinical candidate 2'-beta-fluoro-2',3'-dideoxyadenosine in human plasma. Fast atom bombardment mass spectrometry has been used to characterize the structure of a series of hydroxylated aromatic inhibitors of HIV-1 integrase.